Job Description
The lab RNA in Disease and Translational Technologies at Institute of Molecular and Cell Biology, A*STAR, is looking for two Research Fellows or Senior Research Fellows with experience in mouse/rodent neuroscience techniques for projects related to:
1) RNA therapeutics for brain disorders (partially funded by ESCO Ventures X) – This project is suitable for a postdoc who wants to use neuroscience techniques to investigate a novel therapeutic platform with potential broad applicability); and
2) Molecular and cellular mechanisms that underlie selective cell vulnerability in neurodegeneration and movement disorders – This project is suitable for someone interested in investigating pathophysiological mechanisms of neurodegenerative diseases.
Job Description 1:
The lab of RNA in Disease and Translational Technologies at the Institute of Molecular and Cell Biology, A*STAR, Singapore is seeking to recruit a highly motivated postdoctoral Research Fellow to develop an in vivo system for cell-targeted delivery of RNA therapies for modulation of neuronal circuitry and treatment of brain disorders.
The work will involve both in vitro and in vivo techniques, including molecular biology (RNA handling, in vitro transcription, cell-free RNA assays, RT-qPCR, molecular cloning), cell biology techniques (cell culture, cell transfection, antisense oligonucleotides and RNAi, CRISPR) and experiments in animal models (e.g. transgenesis, functional analyses, neuronal circuit tracing and behavioural assays in mouse and other mammalian models)
Candidates must have a Ph.D. degree in Neuroscience, Biochemistry, Cell Biology, Genetics or a related discipline. The successful candidate will have strong expertise in genetics, cell biology, biochemistry and molecular biology techniques, a solid publication record, and strong scientific writing skills. Experience in genetic models, especially rodent models, is preferred. They will be creative, highly motivated, conscientious and be able to work independently, with good organisational, verbal and interpersonal skills. Our lab is collaborative and interdisciplinary and the successful candidate should be able to work effectively and harmoniously in a diverse team. As a Research Fellow, they will also be expected to mentor and train students and Research Officers.
IMCB provides a competitive remuneration package commensurate with your specific qualifications and experience. We welcome interested applicants to submit a brief cover letter, full CV and contact details of two professional referees to Dr Sherry Aw (syaw@imcb.a-star.edu.sg).
Applications will be accepted until the position is filled. We regret that only shortlisted applicants will be notified.
Job Description 2:
The lab of RNA in Disease and Translational Technologies at the Institute of Molecular and Cell Biology, A*STAR, Singapore is seeking to recruit a highly motivated postdoctoral Research Fellow to investigate the pathophysiology of neurodegenerative movement disorders using detailed movement phenotyping, single-cell RNA-sequencing, molecular-genetic approaches, neuronal circuit tracing and biochemical analysis.
Using a fully automated machine-learning movement tracking algorithm developed in our lab (Wu et. al. PLOS Biology 2019) and an in vivo functional screen, our lab has generated a large dataset of Drosophila movement mutants from which we hope to understand how different neuronal subsets are involved in the onset and progression of movement disorders, including tremor. The project aims to investigate molecular and cellular mechanisms that underlie selective cell vulnerability and specific cellular and behavioural manifestation of neurodegenerative movement disorders using genetic, molecular and biochemical approaches. We are particularly interested in roles for non-coding RNA and RNA regulatory mechanisms.
The work will involve both in vitro and in vivo techniques, including molecular biology, high-throughput/computational approaches, genetics in animal models (e.g. transgenesis, functional analyses and neuronal circuit tracing in Drosophila and mouse) and cell biology.
Candidates must have a Ph.D. in Neuroscience, Biochemistry, Cell Biology, Genetics or a related discipline. The successful candidate will have strong expertise in genetics, cell biology, biochemistry and molecular biology techniques, a solid publication record, and strong scientific writing skills. Experience in genetic models, especially mouse and other rodents, is preferred. They will be highly motivated, conscientious and be able to work independently, with good organisational, verbal and interpersonal skills, and the ability to work effectively in an interdisciplinary team.
IMCB provides a competitive remuneration package commensurate with your specific qualifications and experience. We welcome interested applicants to submit a brief cover letter, full CV and contact details of two professional referees to Dr Sherry Aw (syaw@imcb.a-star.edu.sg).
